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Using the Muscarinic M1 G-protein Coupled Receptor as a model system, we achieved accurate and reproducible determinations of binding affinity (Kd) and IC50 results for known ligands on the 384-well plate device. As a result of being able to incubate the reaction mixture in the filter plate and configure the assay using half the reaction volume, significant reductions in reagent costs and radioactive waste were achieved.

We screen natural products for antimicrobial, antiviral and anticancer activity, immunomodulatory effects, as inhibitors of cell adhesion and antioxidants. High resolution MRI-tomography with 7T magnet (PharmaScan 70/16US, Bruker) allows us to search in situ for compounds with anticancer, anti stroke and anti ischemia activity, inhibitors of angiogenesis and hepatoprotective substances.