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Micro magnetic resonance relaxometry.
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Ascorbic Acid Supplements: A Game Changer for Cartilage Regeneration

Researchers developed a method to enhance mesenchymal stromal cells (MSCs) for cartilage tissue regeneration by adding ascorbic acid during cell expansion. This study also highlights micro magnetic resonance relaxometry (µMRR) as a novel tool.
Cells.
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Real-Time Observation of Organoids Made Possible Using Holotomography

A research team has developed an imaging technology using holotomography, allowing for real-time, high-resolution observation of living organoids. This innovative technique eliminates the need for fluorescent staining.
A group of cells clustered together.
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Tissue Biology Is Shaped by Nutrient Availability and Organelle Signaling

Metabolic factors influence tissue immunity in an intricate interplay between nutrient availability, organelle biology and tissue-resident memory T (TRM) cell development.
Cancer cells.
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CRISPR Gene-Editing Tool Disables Mutation Behind Cancer Drug Resistance

A study reveals that CRISPR gene editing can disable a mutation in melanoma cells that leads to treatment resistance. By targeting the NRAS gene mutation, researchers restored the cells' sensitivity to anticancer drugs.
Cells dividing with strands of DNA in the foreground and background.
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Genome “Jumping Genes” Guide Early Human Development

A critical transition in early human development is regulated by "jumping genes", a new study finds.
Cells.
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How Do Cells Build Their Microtubule Framework?

A study has unveiled the role of CDK5RAP2 in activating the γ-tubulin ring complex (γTuRC), a vital component for microtubule formation in cells. By using cryo-electron microscopy, the team demonstrated how CDK5RAP2 binds to γTuRC.
X chromosomes.
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Integral T Cell Pathway Linked to X Chromosome Inactivation, Shedding Light on Sex-Based Immune Responses

Researchers found that NF-κB, a transcription factor, is essential for maintaining X chromosome inactivation in T cells, connecting immune activation to female genetic processes. The study enhances understanding of sex-biased immune responses.
A top-down image of a petri dish, with cells growing in close proximity, forming a pattern of concentric circles.
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Dividing Cells Adapt to Claustrophobic Environments by Slowing Their Growth

When cells are subjected to physical stress from crowding by their neighbors, they can slow their own growth, forming eye-catching patterns as a result.
Dart board with arrow in bullseye
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Insights Into Protein Degraders for Combatting "Undruggable" Diseases

Researchers have revealed in the greatest detail yet the workings of molecules called ‘protein degraders’ which can be deployed to combat what have previously been regarded as ‘undruggable’ diseases, including cancers and neurodegenerative diseases.
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Mini Brains Reveal Mechanisms Behind Lewy Body Dementia

Scientists created mini-brain models from LBD patients' stem cells, mimicking key disease features. Using these models, they screened nearly 1,300 FDA-approved drugs and identified four potential compounds to inhibit alpha-synuclein buildup.
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