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Protein structure.
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Unraveling Protein Interactions in Cells

Researchers have developed an advanced technique to analyze protein interactions within cells, revealing that cellular stress significantly alters these interactions. The study demonstrates how this understanding could inform drug development.
A target on a cancer cell.
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Cancer Drug May Help Save Limbs in Peripheral Artery Disease

A study reveals that Conatumumab, an existing drug used for cancer treatment, can grow new blood vessels to bypass blockages in patients with Peripheral Artery Disease (PAD). This discovery may lead to significant advancements in treating PAD.
Cancer cells.
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Extrachromosomal DNA Could Be a Future Therapeutic Target for Cancer

Research reveals that higher concentrations of extrachromosomal DNA (ecDNA) in aggressive tumors may aid cancer survival, marking it as a potential target for therapies. The study found ecDNA more prevalent in previously treated patients.
A patient's hand with an IV drip attached.
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Better Use of Existing Drugs Can Increase Cervical Cancer Survival

A short course of chemotherapy before chemoradiation extends cancer-free survival in cervical cancer patients, a new study finds.
Cells.
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Real-Time Observation of Organoids Made Possible Using Holotomography

A research team has developed an imaging technology using holotomography, allowing for real-time, high-resolution observation of living organoids. This innovative technique eliminates the need for fluorescent staining.
Blister packets of different medications
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Experimental Cancer Drug Suppresses Breast Cancer Bone Metastases

In a new study, the drug RK-33 has demonstrated promise in treating breast cancer that has spread to the bone (breast cancer bone metastasis). RK-33 was previously shown to help treat other types of cancer and viral illnesses.
 A hand wearing a white glove holds a syringe filled with yellow liquid.
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Gene Therapy for Gaucher Disease Shows Promise in Mouse Study

An innovative genetic treatment for Gaucher disease has shown promise in mouse models, increasing lifespan and preserving motor function.
Two bags of IV drip medication.
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Drug Extends Survival in Gastric Cancer Clinical Trial

A new study reveals that gastric cancer patients treated with zolbetuximab live longer.
Cells.
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CRISPRmap Enables Spatially-Resolved Interrogation of Gene Function

Researchers developed CRISPRmap, an optical pooled screening approach that links the optical properties of single cells to targeted genetic perturbations. This technique enables high-throughput studies of gene function in complex tissues.
Dart board with arrow in bullseye
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Insights Into Protein Degraders for Combatting "Undruggable" Diseases

Researchers have revealed in the greatest detail yet the workings of molecules called ‘protein degraders’ which can be deployed to combat what have previously been regarded as ‘undruggable’ diseases, including cancers and neurodegenerative diseases.
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