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Blood collection tubes
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CRISPR-Based Rapid Diagnostic for Gene Fusions in Leukemia

New technology that rapidly and simply detects disease-specific molecular alterations in two forms of leukemia could give many more patients access to lifesaving cancer treatments in the U.S. and in resource-limited countries.
Woman applying cream to hands
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Impact of Skin Pigmentation On Drug Bioavailability

The researchers argue that a sizable proportion of drugs and other compounds can bind to melanin pigments in the skin, leading to differences in how bioavailable and efficacious these drugs and other compounds are in people with varying skin tones.
Cancer cells.
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The Cause of a Common DNA Mutation Has Been Challenged

Researchers have discovered that the prevalent cytosine-to-thymine mutations in cancer are mainly due to mistakes in DNA replication rather than spontaneous reactions. The study identifies the role of the DNA-copying enzyme.
Neurons labelled with green, yellow, light blue and dark blue fluorescent staining.
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Gene Therapy Enables Precise Magnetic Field Control of Brain Circuits

A new gene therapy technology enables the non-invasive control of specific brain circuits, holding promise for studying the brain and finding treatments for neurological conditions.
Fluorescent image of a developing human hippocampus.
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Mapping DNA Modification in the Developing Human Brain

Researchers have created a map of DNA modification in two regions of the brain critical to learning, memory and emotional regulation. The map offers a benchmark for ensuring stem cell-based models accurately replicate human brain development.
A crop field.
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Understanding Pathogen Effectors Could Enhance Crop Resistance

A study reveals a DNA sequence linked to pathogen genes that damage wheat. The research, led by CCDM scientists, found that the Pf2 transcription factor activates necrotrophic effectors in Parastagonospora nodorum.
Artistic conceptualization of chromosomal DNA breakdown.
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Antiviral Enzymes Mutate DNA to Promoter Early Bladder Cancer Development

Researchers discovered that antiviral enzymes induce early mutations in bladder cancer, and standard chemotherapy causes additional mutations. The study highlights the role of complex DNA rearrangements in treatment resistance.
A glass of wine.
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Alcohol Exposure Affects Epigenetic Regulation in the Placenta

Researchers discovered that alcohol exposure prior to embryo implantation leads to significant molecular changes in the placenta, including altered gene expression and DNA methylation.
A used toothbrush.
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Your Toothbrush and Showerhead Are Covered in Viruses

Researchers from Northwestern University identified over 600 unique viruses in household environments, such as toothbrushes and showerheads. The study highlights the diverse viral communities present and their potential implications for human health.
Cells.
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Diabetes-Linked DNA Changes Disrupt Pancreatic Cells’ Stress Resilience

Research identifies how DNA sequence changes linked to diabetes risk affect pancreatic cell stress responses. The study shows that stressors like inflammation and high blood sugar can overwhelm insulin-producing cells.
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