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Antibodies.
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New Antibodies Could Mitigate Opioid Side Effects

Scientists developed a nanobody, NbE, that binds tightly to opioid receptors, blocking their activity. This could mitigate the severe side effects of opioids and lead to the creation of smaller, more effective molecules.
The human alveolar macrophage-like (AML) model contains many of the critical features of alveolar macrophages found in the lungs, including onion-shaped phagolysosomes (left) and the cell nucleus (right).
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Human Cell Model Aids Understanding of Tuberculosis

A study utilizing alveolar macrophage-like (AML) cells revealed that tumor necrosis factor (TNF) is critical for fighting tuberculosis but not other infections. The findings challenge existing beliefs about TNF's immune functions.
The structure of a protein.
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AlphaFold Wins the Nobel Prize in Chemistry 2024

David Baker, Demis Hassabis and John Jumper have been awarded the 2024 Nobel Prize for Chemistry for their work on computational protein design and protein structure prediction.
Fluorescent mitochondria cell
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You Have Your Mother's Energy

Researchers shed light on why only maternal DNA is inherited inside the mitochondria and why if paternal mitochondria slips into a developing embryo, it can lead to lasting neurological, behavioral and reproductive problems in adults.
Cells.
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Diabetes-Linked DNA Changes Disrupt Pancreatic Cells’ Stress Resilience

Research identifies how DNA sequence changes linked to diabetes risk affect pancreatic cell stress responses. The study shows that stressors like inflammation and high blood sugar can overwhelm insulin-producing cells.
Dark grey blobs form with a neuron.
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The Immune System Plays an Unexpected Role in Lewy Body Formation

Researchers have replicated the formation of Lewy bodies and revealed the key role of immune challenge in the process.
Cells.
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Key RNA Molecule Identified for Enhancing Skin Wound Healing

Researchers have identified the lncRNA SNHG26 as a key regulator in skin wound healing. The study shows SNHG26’s role in transitioning from inflammation to tissue repair, paving the way for new therapeutic approaches for chronic wounds.
Chromosomes (blue) with proteins (green, red) localized at the centromere.
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Understanding the Centromere, the Key to Cell Division Maintenance

Researchers discovered the molecular mechanism regulating the replenishment of centromeric protein A (CENP-A) at the centromere. The study reveals how Polo-like kinase 1 (PLK1) initiates the assembly of the machinery necessary for CENP-A reloading.
A clipboard with the words "autoimmune disease" written on it.
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CRISPR-Modified Cells Offer Remission for Autoimmune Patients

Three patients are in “safe, deep remission” after receiving a CRISPR-Cas9-modified cell therapy for autoimmune disease treatment, according to a new published study in Cell.
Cells.
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Comb Jellies Merge After Injury for Survival

A study discovered that the comb jelly Mnemiopsis leidyi can fuse after injury, merging two individuals into one. This fusion allows them to synchronize muscle contractions and share digestive functions.
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