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New Antibodies Could Mitigate Opioid Side Effects
Scientists developed a nanobody, NbE, that binds tightly to opioid receptors, blocking their activity. This could mitigate the severe side effects of opioids and lead to the creation of smaller, more effective molecules.

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Human Cell Model Aids Understanding of Tuberculosis
A study utilizing alveolar macrophage-like (AML) cells revealed that tumor necrosis factor (TNF) is critical for fighting tuberculosis but not other infections. The findings challenge existing beliefs about TNF's immune functions.

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AlphaFold Wins the Nobel Prize in Chemistry 2024
David Baker, Demis Hassabis and John Jumper have been awarded the 2024 Nobel Prize for Chemistry for their work on computational protein design and protein structure prediction.

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You Have Your Mother's Energy
Researchers shed light on why only maternal DNA is inherited inside the mitochondria and why if paternal mitochondria slips into a developing embryo, it can lead to lasting neurological, behavioral and reproductive problems in adults.

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Diabetes-Linked DNA Changes Disrupt Pancreatic Cells’ Stress Resilience
Research identifies how DNA sequence changes linked to diabetes risk affect pancreatic cell stress responses. The study shows that stressors like inflammation and high blood sugar can overwhelm insulin-producing cells.

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The Immune System Plays an Unexpected Role in Lewy Body Formation
Researchers have replicated the formation of Lewy bodies and revealed the key role of immune challenge in the process.

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Key RNA Molecule Identified for Enhancing Skin Wound Healing
Researchers have identified the lncRNA SNHG26 as a key regulator in skin wound healing. The study shows SNHG26’s role in transitioning from inflammation to tissue repair, paving the way for new therapeutic approaches for chronic wounds.

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Understanding the Centromere, the Key to Cell Division Maintenance
Researchers discovered the molecular mechanism regulating the replenishment of centromeric protein A (CENP-A) at the centromere. The study reveals how Polo-like kinase 1 (PLK1) initiates the assembly of the machinery necessary for CENP-A reloading.

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CRISPR-Modified Cells Offer Remission for Autoimmune Patients
Three patients are in “safe, deep remission” after receiving a CRISPR-Cas9-modified cell therapy for autoimmune disease treatment, according to a new published study in Cell.

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Comb Jellies Merge After Injury for Survival
A study discovered that the comb jelly Mnemiopsis leidyi can fuse after injury, merging two individuals into one. This fusion allows them to synchronize muscle contractions and share digestive functions.
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