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Latest App Notes & Case Studies

Achieving Method Modernization with the New Liquid Chromatographic Gradient Allowances Provided by USP General Chapter <621> Chromatography and the Alliance™ iS HPLC System
App Note / Case Study

Achieving Method Modernization with the New Liquid Chromatographic Gradient Allowances

USP monograph gradient separations can be successfully adjusted to maintain system suitability acceptance criteria on the Alliance iS HPLC System, as per the General Chapter <621> Chromatography (December 1, 2022).
Drinking water being poured into glass
App Note / Case Study

Streamline PFAS Detection Using Automated Solid-Phase Extraction and LC-MS/MS

This application note highlights how an automated solid-phase extraction (SPE) system can provide reliable, sensitive and accurate determination of PFAS in large-volume samples.
A collection of variously colored pebbles on a beach with a small wave approaching; a single heart-shaped red stone is prominently featured among the other pebbles.
App Note / Case Study

Comprehensive Software for Untargeted PFAS Analysis Using HRAM Spectrometry

This application note presents a powerful software that provides a comprehensive turnkey solution for the untargeted analysis of PFAS using HRAM spectrometry.
A chemical structure in front of a waterway
App Note / Case Study

Detecting PFAS Contamination Using Combustion Ion Chromatography

This application note describes how combustion ion chromatography (CIC) can provide a precise and automated method for analyzing a wide range of PFAS and their precursors, enhancing understanding of contamination levels and associated health risks.
An image of a person in a red top filling a glass with water from a kitchen tap
App Note / Case Study

Advanced PFAS Detection in Drinking Water Using High-Resolution Accurate Mass Spectrometry

This application note presents a validation of the EPA Method 537.1 using automated solid phase extraction (SPE) combined with HRAM spectrometry.
A handful of soil with various analytical parameters measuring temperature, elements, pH and more.
App Note / Case Study

Advanced Techniques for PFAS Analysis in Soil

This application note showcases the effectiveness of accelerated solvent extraction in isolating various PFAS compounds—including acids, sulfonates, fluorotelomer sulfonates, and sulfonamide compounds—from soil samples.
High-throughput high-resolution data-independent acquisition workflow on an Orbitrap Exploris 480 mass spectrometer for accurate label-free quantitation
App Note / Case Study

Optimized Approaches for High-Throughput Protein Quantitation

This tech note explores the integration of automated sample preparation, robust LC-MS/MS analysis, and advanced data analysis software to achieve high-throughput and accurate label-free quantitation.
Scientist Handling Testing Kit with hands in protective gloves stock photo
App Note / Case Study

Rapid Detection of Mutations Using ddPCR

This application note showcases a Droplet Digital PCR (ddPCR) workflow that can detect mutations commonly associated with non-small-cell lung cancer (NSCLC) in a single-well, 6-plex reaction.
A factory producing air pollution
App Note / Case Study

High-Throughput Analysis of PFAS in Air

This application note showcases a fast, high-throughput approach to measure 19 target PFAS compounds with precision and efficiency.
Green leaf floating in polluted water
App Note / Case Study

The Benefits of Hydrogen Carrier Gas in PCB Analysis

This application note demonstrates how hydrogen carrier gas can be used in place of helium for GC-MS/MS analysis of PCBs, giving laboratories greater flexibility and ensuring sustained, cost-effective operations.
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